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She added that the consistency of the decreased likelihood of dementia diagnosis across the different medications was particularly noteworthy. Past studies have reported associations between GLP-1 receptor agonists and dementia, with some suggesting a reduced dementia risk after starting the medication and others indicating variability depending on how these medications cross the blood-brain barrier, Bartlet and colleagues wrote

In contrast, mechanisms supported by weak or preliminary evidence [e.g., the vitamin C/gut microbiota/depression axis (152, 153), and the calcium/gut microbiota/depression axis (218220)] require further validation

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