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Footnotes AUTHOR CONTRIBUTIONS: G Liu and C Deng designed and guided the whole study and revised the manuscript

Investigation Areas Peptideexcipient and vehicle compatibility (gels, serums, lotions) Stability screening: pH, temperature, light, and oxidation Copper complexation and redox/chelation behavior in model systems In-vitro assay development and comparative peptide benchmarking Particle handling, dissolution, and solubility characterization Handling Requirements Qualified personnel in equipped laboratories Use calibrated balance