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They are often caused by environmental factors like pollution, UV radiation, and stress

These can happen after a sudden injury or from repeated strain

Left untreated, a vitamin B-12 deficiency can lead to anemia, fatigue, muscle weakness, intestinal problems, nerve damage and mood disturbances

110 - 116 Copyright Copyright The Authors 2008 Over the last few years, increasing evidence has shown that hyperhomocysteinaemia is an independent risk factor for the development of CVD ( Reference Wyss and Schulze 1 , Reference Harbor-Gonalves, Vaz and Bezzi 2 ) and may be associated with neurodegenerative disease ( Reference Obeid and Herrmann 3 , Reference Bender, Koch and Elstner 4 ) , diabetes ( Reference Wijekoon, Brosnan and Brosnan 5 ) and end-stage renal dysfunction ( Reference Taes, Delanghe and De Vriese 6 , Reference Taes, Delanghe and De Bacquer 7 )

Hemolysis and jaundice in the newborn following maternal treatment with sulfamethoxypyridazine (kynex)