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Upon intravenous injection into the tail vein, the nanoparticles selectively accumulated in the tumor of the animal model

GPx-1 (gluthathione peroxidase 1) helps to prevent oxidative stress by getting rid of one ROS in particular: hydrogen peroxide ( H2O2 )

IGF-1, as a nutrient-responsive growth factor, activates NF-B and the expression of downstream genes (Ccdn1, Vegf, Birc5 and Ptgs2) to promote the growth of pancreatic cancer in vitro and in vivo (88)

This effectively downregulates CTLs activity and alleviates tissue damage (119)

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