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Notably, the proteins indicated with gray hair also play a role in mitochondrial metabolism and the NAD+ pathways

A composite analysis of 8 cardiovascular outcomes trials completed in 2021 demonstrated reduced incidence of major cardiovascular events by 14% and cardiovascular death by 13% (NCT01147250, NCT01179048, NCT01720446, NCT01144338, NCT02465515, NCT01394952, NCT02692716, NCT03496298)

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Evolutionarily, the origin of RCD, in particular, apoptosis has been postulated to be associated with endosymbiosis, i.e., domestication of mitochondria [137,138,139]