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Other serious risks include acute pancreatitis, acute kidney injury (often from dehydration caused by stomach side effects), low blood sugar (especially when combined with insulin or a sulfonylurea), diabetic retinopathy complications, gallbladder disease, and allergic reactions

This study also confirmed the wound-healing ability of graphene oxide (GO)/metformin (Met) hydrogels in vivo, indicating their wound healing-promoting effect in diabetic wounds [154]

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While GPX3 localized mainly to the basement membrane of the bronchial epithelium and endothelium in healthy mouse and human tissue, we found localization also to the interstitial ECM in fibrotic tissue compartments