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Ex-4 has similarly been shown to inhibit the proliferation of prostate and breast cancer cells via suppression of the same pathway [65]
therefore, its combination with a strong CYP3A4 inducer, such as rifampin, should be avoided if possible
Several landmark cardiovascular outcome trials have demonstrated that GLP-1RAs can significantly reduce the risk of major adverse cardiovascular events (MACE), which include cardiovascular death, nonfatal myocardial infarction (heart attack), and nonfatal stroke [43]
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