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Participants were randomly assigned to semaglutide 2.4 mg once weekly (n=35) or placebo (n=35), alongside lifestyle intervention incorporating a 500 kcal daily energy deficit and increased physical activity

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Furthermore, antihypertensive drugs that do not block the SNS may exhibit an increasing BP effect of DPP-4 inhibitors by lowering basal vascular tone (86)

Many discovered they were mid-protocol when coverage ended, creating an urgent need for affordable alternatives

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