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In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising -D-glucopyranosyl--glycopyranoside, n-Dodecyl-4-O--D-glucopyranosyl--glycopyranoside, and/or n-tetradecyl-4-O--D-glucopyranosyl--glycopyranoside

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Within the results, it was found that the liver fat content decreased significantly in the group that received luseogliflozin, an SGLT2 inhibitor, compared with that in the metformin group [64]