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In our study, FOXO4-DRI selectively induced apoptosis in senescent keloid fibroblasts by promoting the relocation of p53-pS15 from the nucleus to the cytoplasm, exhibiting similar clearance efficiency to that in normal skin fibroblasts

A toxic intermediate compound up to 30 times more harmful than ethanol itself

For instance, oxidative stress induces S-sulfinylation of the catalytic Cys residue in Prx1, inactivating the enzyme

Some patients report diffuse pain

103 Liraglutide similarly ameliorates MASH by enhancing mitophagy in animal models, 163 highlighting the dual autophagy-mitophagy actions of clinically approved agents