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Treatment of alloxan-induced diabetic rats with metformin or glitazones is associated with amelioration of hyperglycaemia and neuroprotection

Image Credit: siamionau pavel / Shutterstock Background Weight loss reduces obesity-related comorbidities but often leads to decreased bone mineral density (BMD) and increased bone turnover, raising fracture risk and mortality

Kele S, Caner I, Ate O, akici , Saruhan F, Mumcu UY, Alp HH (2014) Protective effect of L-carnitine in a rat model of retinopathy of prematurity

Why it matters: Flattened or inverted cortisol curves lead to exhaustion and cellular stress

3 Other factors such as dietary risks, environmental or occupational risks, tobacco use, low physical activity alcohol use all account for part of the risk of T2D