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Methionine oxidation Methionine residues are particularly vulnerable to oxidation by dissolved oxygen and reactive oxygen species

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NNMT is not simply a metabolic toxin The enzyme and its products have physiological roles

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The most pronounced differences were observed across gastrointestinal and metabolic events, including nausea (9,651 vs 38,030), vomiting (4,383 vs 17,062), pancreatitis (1,389 vs 6,655), and hypoglycaemia (773 vs 1,778), all substantially lower with combination therapy (Table 1)