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doi:10.1038/s42255-023-00917-5

A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

Absorption depends on intrinsic factor in your guta protein that declines with age

Helps protect digestive function and counter the damaging effects that NSAIDs like Ibuprofen and Advil can have on the lining of the gut

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