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The 10 mg/day arm showed a smaller reduction than the 1 mg group, confirming the absence of a dose-dependent response above the threshold range

In fact, MS was one of the first CNS diseases where gut bacteria were shown to have a causal influence in animal models: in 2011, it was demonstrated that segmented filamentous bacteria in the gut could trigger CNS-autoreactive Th17 cells and provoke an MS-like disease in mice [181]

Improved Skin Appearance: Vitamin B12 plays a significant role in skin health

The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation

Downstream tissue effects persist substantially longer