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SIRT1 is also known as the longevity gene because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer

B12 is involved in metabolism and energy production, so if a deficiency is contributing to low energy and making it hard to exercise, injections might indirectly support weight loss efforts by boosting energy

In these people, pernicious anemia develops at about age 60

Kaplan GG, Ng SC

The frequency of Vitamin B12 injections can vary based on individual needs, health status, and the severity of the deficiency