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To avoid side effects, it is recommended to start with lower doses (100-200 mg) and gradually increase as needed

Integrated transcriptmetabolite analysis revealed coordinated regulation across major biosynthetic networks (Fig 7I)

Finally, advanced imaging (MRI or CT) and/or electrodiagnostic testing (EMG/NCS) may help to further solidify the diagnosis

This system is highly expressed in astrocytes, the main GSH synthesizing cells in the brain, and is regulated by various factors, including oxidative stress and inflammatory cytokines Once synthesized, GSH can be metabolized by various enzymes, including glutathione S-transferases (GSTs), which conjugate GSH with xenobiotics and endogenous electrophiles for elimination, and gamma-glutamyl transpeptidase (GGT), which cleaves GSH into its constituent amino acids and generates extracellular glutamate, a major neurotransmitter in the brain

The reaction mixture was heated (100C) for 1 hr, absorbance taken at 532 nm in a spectrophotometer