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They help maintain already healthy homocysteine levels.* And, as part of a well-balanced dietthats low in saturated fat and cholesterolfolate, vitamin B6, and vitamin B12 may reduce the risk of vascular disease

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Unfortunately, our understanding of this is still in its infancy, due to scarce availability of comparison data between women who experience loss of trisomy 21 pregnancies and those with trisomic fetuses that survive up to the birth, as well as to a few epigenetic studies in DS individuals