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Data from Phase 2 trials (Jastreboff et al., NEJM 2023) provide the most detailed safety information currently available, though it is important to recognise that longer-term safety data from Phase 3 trials are still being gathered

The guidelines state, GLP-1 RAs may be considered for weight-loss in patients who have completed cancer therapy and may be considered with caution for patients on stable endocrine-based cancer therapies based on limited observational safety data. They also say, GLP-1 RAs cannot be recommended currently for patients receiving or initiating chemotherapies and/or immunotherapies due to lack of safety and outcomes data. Iyengar is director of Survivorship Services at Winship Cancer Institute of Emory University, a clinical member of Winships Glenn Family Breast Center, an associate professor and co-director of the Breast Medical Oncology Program in the Department of Hematology and Medical Oncology at Emory University School of Medicine, and co-editor-in-chief of the journal ONCOLOGY

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Furthermore, these strategies overcome the problems related to the short half-life of drugs in the blood, avoiding the ones related to systemic exposure and toxicity [8]

Clinical scope The program does not function as a primary care service or replace an ongoing clinician relationship