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Chemokine (C-X-C motif) receptor 4 (CXCR4) expression increases during progression of PCa and is associated with metastatic disease and poor survival [50, 51] CXCR4 selectively binds to stromal cell-derived factor 1 (SDF-1)/ CXCL12, also overexpressed in PC metastatic tissue compared to normal tissues [52]

The most important adverse effects of LDL-apheresis include: hypotension, abdominal pain, nausea, vomiting, vertigo and headache, hypocalcaemia, iron deficiency anaemia, allergic reactions, haemolysis, and thrombocytopenia

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It regulates cytokines (TNF-, IL-6), decreases swelling, and limits immune-cell overactivity

For moderate deficiency, once or twice weekly injections for 4-6 weeks usually does the trick