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To examine the effect of small studies, publication bias was assessed using a comparison-adjusted funnel plot and Eggers test

The underlying reason is that the peptides as therapeutic agents are better than the chemical drugs in providing greater safety, target specificity and potency 1,2,3,4,5

Patton, J

Effects of dexamethasone on the availability of L-tryptophan and on the insulin and FFA concentrations in unipolar depressed patients Biol Psychiatry 1990