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When ROS levels exceed the antioxidant defenses, spermatozoa are subjected to oxidative stress, leading to detrimental molecular changes, including lipid peroxidation, DNA fragmentation, and protein oxidation

Another study reported that the inhibition of lncRNA ZFAS1 upregulated cardiac GPX4 and terminated the ferroptosis process and oxidative insult in DCM mice [95]

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IGF-1 and Longevity Research has shown that while decreased levels of GH and IGF-1 lead to the deterioration of various physiological functions, these decreased levels have also shown promise in increasing life span

Tirzepatide represented the second generation of this research, introducing a unimolecular dual agonist approach