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Behaving as the terminal electron acceptor during cellular respiration, the high rate of O 2 electron flux is accompanied by an increased risk of ROS formation, which can induce irreversible damage to cellular organelles and their processes (Case 2017)

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GHK is a naturally occurring tri-peptide that consists of the amino acids glycine, histidine, and lysine

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335,336 The expression of iNOS is primarily activated by the NF-B pathway, which is activated and translocated to the nucleus upon inflammatory stimulation (such as bacterial endotoxins or pro-inflammatory cytokines), thus increasing the transcription and expression of iNOS