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Genes encoding membrane transporters are also critical to the normal responses of -cells to glucose metabolism including KCNJ8 (K ir 6.1), KCNJ11 (K ir 6.2), KCNQ1 (K v 7.1), SLC39A11 (zinc transporter), SLC30A8, and SLC22A18

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KEGG pathway enrichment results indicated that DEGs between the NCD and HFD groups were significantly enriched in pathways such as the chemokine signaling pathway, ECM-receptor interaction, lysosome, focal adhesion, tight junction, cell cycle, insulin resistance, glutathione metabolism, fatty acid metabolism, glycerolipid metabolism, and cholesterol metabolism (Fig

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