In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]
90%, respectively, by the above procedure
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Liu T, Xu X, Li J, Bai M, Zhu W, Liu Y, et al
Results vary, and treatment should only be considered under medical supervision