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Metaxas et al., 2017

Additionally, metformin inhibits M.tb growth, induces mitochondrial ROS production, promotes phagosomelysosome fusion in vitro, ameliorates pulmonary pathology, attenuates chronic inflammation, augments immunity, and improves the therapeutic effect of the standard anti-TB regimen in M.tb -infected mice

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Non Alcoholic Fatty Liver Disease Non-alcoholic fatty liver disease (NAFLD) exists as a continuum of disease ranging from extreme buildup of fat within the hepatic parenchyma (simple steatosis), inflammation (non-alcoholic steatohepatitis, NASH) to fibrosis, cirrhosis, end-stage liver disease, and there is also an increased risk of hepatocellular carcinoma (HCC)