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As the main structural component of the Lewy body, alpha-synuclein mainly resides in neurons and is primarily expressed in cerebral cortex, hippocampus, substantia nigra, thalamus, and cerebellum, and is also found in glia
Under normal physiological conditions, activation of the Keap1-NRF2 signaling pathway promotes the activation of System Xc - and the expression of GPX4 and accelerates cysteine glutamate transport, thereby clearing accumulated lipid peroxidation and inhibiting ferroptosis (86)
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La supplmentation de glutathion restaure les niveaux de cet antioxydant et rduit les dommages oxydatifs