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In one study, investigators assessed changes in testosterone after low, moderate, or high intensity aerobic exercise on an exercise bike and found that only high-intensity exercise increased testosterone

Following additional studies, the FDA also approved their use for weight loss in 2014

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However, these studies found no significant improvements in a range of safety endpoints for cardiovascular diseases ( The Role of DPP-4 Inhibitors in Hypertension The first DPP-4 inhibitor, sitagliptin, was approved as an anti-hyperglycemic agent for T2DM in the United States of America in 2006