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The glutathione pathway may also supply glutamate when glia derived glutamine is blocked by MeAIB, which inhibits system A transporters

10.1002/pros.23895 131 PengD.ZhangH.SunG

Compromised intestinal epithelial barrier due to intestinal epithelial-specific loss of JAM-A induces adaptive immune compensation that protects from colitis The findings in mice manipulated for MLCK or occludin expression differed from those obtained in mice lacking the JAM-A (encoded by F11r)

The copper complex itself is not optional decoration: the copper ion is what activates the receptor signaling at fibroblast surfaces