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Animal studies suggest it has a strong safety profile with no toxicity at high doses

When cytoplasmic concentrations of neurotransmitters rise dangerously high, TAAR1 activates G-protein-dependent signaling pathways that recruit intracellular kinases, including protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaMKII) (Underhill et al., 2020)

Poikiloderma of Civatte: this condition is recognized by a web-like pattern of dark pigmentation, along with fragile blood vessels (telangiectasia), and thinning skin (atrophy) specifically on the sides of the neck

Critical Rev Oncol/Hematol 98:235241 Wang LC, Almazan G (2016) Role of sonic hedgehog signaling in oligodendrocyte differentiation

Protein Cell 8 , 169177 (2017)