A drug in development and undergoing clinical trials could be considered prohibited if it falls into one of the categories of banned substances on the WADA Prohibited List, or if it has the potential to be performance enhancing
Studies in Caco-2 cell monolayers (a cellular model of human intestinal epithelium) have shown that metformin is efficiently taken up across the apical (luminal-facing) surface of enterocytes via bidirectional transporters, but that efflux across the basolateral surface of enterocytes is limited, resulting in the accumulation of metformin in the epithelium [16], possibly accounting for the greatly increased metformin concentration seen in these cells
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Although there are no direct models of DLB, evidence can be extrapolated from PD models and clinical studies, which (as above) demonstrate GLP-1RAs exert broad neuroprotective actions: attenuating pathological protein aggregation, improving impaired insulin signaling, and reducing neuroinflammation
