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Corcoran GB, Racz WJ, Smith CV, Mitchell JR: Effects of N-acteylcysteine on acetaminophen covalent binding and hepatic necrosis in mice

MRS data were collected using a 1 H-MRS single voxel short TE STEAM (STimulated Echo Acquisition Mode) sequence (TE/TM/TR = 17/17/2000 ms) with eight phase cycle steps, 4096 samples, and a 4 kHz bandwidth

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Mechanistically, MT1G exerts a negative regulatory effect on NF-B signaling and facilitates the degradation of the NF-B p65 subunit by upregulating the expression of E3 ligase TRAF7, consequently suppressing PDAC stemness