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The above experiments in vivo and in vitro have confirmed that TMAO can cause inflammation of endothelial cells, and similar results can be observed in humans

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Jama 318(15):14601470 Davies M, Pieber TR, Hartoft-Nielsen M-L, Hansen OK, Jabbour S, Rosenstock J (2017) Effect of oral semaglutide compared with placebo and subcutaneous semaglutide on glycemic control in patients with type 2 diabetes: a randomized clinical trial