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Additionally, co-administration of nicotine with liraglutide has additive inhibitory effects on food intake and body weight associated with increased activity of dopaminergic VTA neurons [101], while the GLP-1-MK-801 conjugate similarly has additive effects on food intake and body weight associated with increased activity of VTA neurons [60]

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For diarrhoea, Saccharomyces boulardii has robust evidence across multiple aetiologies, including antibiotic-associated diarrhoea as demonstrated in Cochrane reviews, and may theoretically help when diarrhoea occurs with semaglutide