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19% of Americans have used a GLP-1 medication

An analysis of a T2DM cohort based on metagenomic sequencing and validated in an independent cohort found that metformin-treated patients had an increase in Escherichia coli and a decrease in Intestinibacter , and that the abundance of several intestinal microbial genera was more similar to that of normal control levels, particularly Akkermansia (Forslund et al., 2015)

It is one of the most abundant phospholipids in the human body and a primary component of every cell membrane

This highlights the need to consider gut microbial balance when evaluating prolonged PPI therapy

Cervantes-Navarro, F