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Individual targets vary based on starting weight, exercise level, and baseline metabolism

The reduction of SIRT4 affects mitochondrial fusion and fission and reduces ATP synthesis, leading to mitochondrial dysfunction and the large amounts of ROS, thereby enhancing renal oxidative stress in db/db mice and promoting the development of DKD (Liang et al., 2023)

HDL-P was found to be inversely associated with carotid intima medial thickness (cIMT) and coronary heart disease (CHD) independent of LDL particle numbers and HDL-C levels in the large multi-ethnic study of atherosclerosis (MESA) (756)

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