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According to the protein misfolding avoidance hypothesis, natural selection disfavors the misfolding of highly expressed proteins, thereby constraining their evolution to minimize cytotoxicity 38

Fsp1 knockout enhanced CaOX-induced ferroptosis in MTECs To further investigate the role of Fsp1 in oxalate-induced AKI, the CRISPR-Cas9 system was employed to create Fsp1 knockout MTECs and confirmed through Sanger sequencing and Western blot analysis (Fig

It is imperative to research novel avenues targeting immune checkpoint receptor proteins because of the treatment resistance, poor response, or considerable increase in toxicity of antibody medicines targeting PD-1/PD-L1 or CTLA-4 that have previously been found [222, 223]

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