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It is generally attributed to DNA damage from smoke and other chemicals from tobacco that trigger abnormal cell changes

Three years after implementation, an estimated 84,300 youths from over 200 schools in Philadelphia benefited from a reduction in tobacco retailers near their schools, including more than 10,500 youths who had their school zone exposure drop to zero, the article states

Interventions for promoting smoking cessation during pregnancy

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The MRTP process is a consequence of the 2009 Tobacco Control Act, which was strongly supported by Philip Morris