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Unlike medications requiring therapeutic drug monitoring (such as immunosuppressants or certain antibiotics), tirzepatide dosing is standardized based on clinical response and tolerability rather than serum concentrations

The log 2 fold change values were shrunk with the CRAN ashr (v2.2.-54) package (Stephens, 2017), whereas two-tailed P -values obtained from Walds testing were adjusted with the Bioconductor Independent Hypothesis Weighting (v1.16.0) package (Ignatiadis et al, 2016)

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