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The duration of therapy for intranasal treatment is tested, commonly used, and deemed safe for at least 18 months

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Also, an extension from stomach epithelium protection to stomach endothelium protection (and thereby concept background stomach endothelium stomach epithelium protection) (21-24) permits cytoprotective agents as an endothelium protectants class (although this was not originally claimed) (21-24), and consequently, application in thrombosis and bleeding disorders (5, 8, 25-28)