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21 Six studies investigated the association of comorbid depression and anxiety with later smoking onset, of which two (33%) found evidence to support this association, 31,32 while one (17%) reported comorbid depression and anxiety was associated with reduced risk of smoking onset 33 and three (50%) found no evidence of an association

You can visit fbi.gov/AheadOfTheThreat to listen to episodes, read the transcripts, and find related material

13 A company seeking to market an ENDS as an actual smoking cessation tool (i.e., with smoking cessation claims) such as the nicotine gum or patch would need FDA premarket approval as a drug, because smoking cessation claims trigger the first prong of the drug or device definition, described above

cigarette smoking on endothelial function by brachial artery duplex ultrasonography: an observational study