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Possible causes of endolymphatic hydrops include: Blockage of the endolymphatic duct Abnormal immune response Viral infection Head trauma Genetic predisposition The pathophysiologic sequence of events in Menieres disease includes: Endolymphatic hydrops Rupture of the membranous labyrinth Mixing of endolymph and perilymph Damage to hair cells and other inner ear structures This damage to the inner ear can lead to the classic symptoms of Menieres disease, including: Episodic vertigo: A spinning sensation that can last for minutes to hours

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Lipid metabolism has been reported to be disrupted in fibrotic lungs [7, 34] and participate in fibroblast activation [35]

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