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Macrophages are central to this process, orchestrating immune responses via cytokine secretion, phagocytosis of pathogens, apoptotic cells, and ECM debris, and facilitating tissue remodeling by releasing proteolytic enzymes and their inhibitors (135)

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Whole-blood histamine, SAM, SAH, methionine, homocysteine, symptoms and nutrient response can provide more useful information than an MTHFR result alone