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Anatomical proximity to radiosensitive organs such as the bladder, rectum, and bowel restricts dose escalation and exposes patients to long-term toxicities including fibrosis, necrosis, sexual dysfunction, and urinary or bowel complications [14,15,16]

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The published evidence base for CJC-1295 Without DAC draws on both the direct characterisation of the tetrasubstituted backbone and the extensive clinical and pre-clinical literature generated for CJC-1295 with DAC, which shares the same four amino acid substitutions and GHRH receptor pharmacology

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