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Studies indicate that the gene expression profiles of individuals with depression differ significantly from those of healthy individuals

The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis

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Although antioxidants have demonstrated protective effects in animal and cell models, their clinical efficacy remains unstable ( Among the candidate target genes, GSTM1, a member of the glutathione S-transferase (GST) family, is located on human chromosome 1 and is an essential component of cellular antioxidant defense