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Novel guidelines for testing nanomaterials have been developed within the Malta Initiative since 2017, and the launch of EU-funded projects, including the Horizon 2020-funded NanoHarmony, RiskGONE (Science-based Risk Governance of NanoTechnology), NANORIGO (NANOtechnology RIsk Governance), or Gov4Nano

Currently, the main limitation of organoids in terms of cellular complexity is the apparent lack of luminal cells and associated spatial organization