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signed off on it but questioned aspects of its safety

Less frequent dosing would result in lower trough concentrations and reduced efficacy

It does help reduce cravings, which can help reduce calorie intake

Higher drug concentration and estrogen sensitivity : These sex-based differences may be due to higher drug levels in smaller bodies and how estrogen interacts with GLP-1 signaling , which could heighten sensitivity to side effects

In addition, Novo Nordisk conducted a pooled analysis of all randomized, placebo-controlled trials of liraglutide and semaglutide (involving more than 96,000 patients) and found no increased risk of NAION associated with either GLP-1 therapy." Wirth lost a lot when she lost her eyesight