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Bioinspired nanogel composed of DNase I and a polylysine dendrimer (G3K) showed potent DNA trapping abilities while retaining nearly 90% of the biological activity of DNase I, making it effective in scavenging cfDNA (98)

Moreover, the inherent functional duality of LONP1 mandates a rigorous riskbenefit assessment for any intervention to establish an optimal therapeutic window

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