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In vivo experiments have demonstrated that nicotine can induce the activity of various enzymes within the central nervous system (CNS), including CYP2E1, CYP2A1/2A2, and CYP2B1/2B2 (Anandatheerthavarada et al., 1993a

[6] In 1880, he had a first working prototype, which was destroyed by a fire while in storage at Lynchburg, Virginia

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