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During Weeks 8 and 9 of the trial, NTS was tapered to 14 and 7 mg per day, respectively

Briar Fox is an exceptionally smooth mixture of Virginias and Burley, and the personal blend of well-known Danish pipe maker, the late Peter Heeschen

Wooden or bone pipe tamper in an 18th- or 19th-century style

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The detailed chemicals and analytical method is provided in Supporting Table 2