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7 Long-term toxin exposure contributes to the development and progression of serious diseases including cardiovascular disease, Parkinsons disease, and cancer

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Data Extraction The following information was extracted from each of the included studies, by one author (MF): type of depression/anxiety (major depression, generalized anxiety disorder, mixed major depression, and generalized anxiety disorder), method of measuring depression/anxiety (self-report via diagnostic test, clinical interview, or physician diagnosis) and scale used (continuous or categorical), smoking behavior (age of smoking onset, smoking status, heaviness of smoking, tobacco dependence, smoking trajectory), sample size, mean age of participants and sex distribution of participants, population sampled (eg, general or clinical), and length of follow up

Since it becomes habitual, dependency can develop over time